Asymptomatic Carotid Atherosclerosis in a Community Population Serum Ferritin and C282Y Mutation of the Hemochromatosis Gene as Predictors of
نویسندگان
چکیده
Enrico Rossi, Brendan M. McQuillan, Joseph Hung, Peter L. Thompson, Conchita Kuek and Asymptomatic Carotid Atherosclerosis in a Community Population Serum Ferritin and C282Y Mutation of the Hemochromatosis Gene as Predictors of Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.31.12.3015 2000;31:3015-3020 Stroke. http://stroke.ahajournals.org/content/31/12/3015 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Serum ferritin and C282Y mutation of the hemochromatosis gene as predictors of asymptomatic carotid atherosclerosis in a community population.
BACKGROUND AND PURPOSE Serum ferritin and heterozygosity for the C282Y mutation of the hemochromatosis gene have both been associated with an increased risk of cardiovascular events. The purpose of the study was to test whether either is a risk predictor for asymptomatic carotid atherosclerosis. METHODS We assessed carotid intima-media wall thickness (IMT) and focal plaque formation by high-r...
متن کاملFrequency of C282Y and H63D Mutations of HFE Gene and Their Correlation with Iron Status in Iranian Beta-Thalassemia Major Patients
Background: Co-inheritance of hemochromatosis (HFE) gene mutations may play an essential role in the pathogenesis of iron overload in beta-thalassemia major (BTM) patients. The present study aimed to investigate the prevalence of HFE C282Y and H63D mutations in BTM patients and their correlation with some demographic data and biochemical iron markers. Materials and Methods: The study populat...
متن کاملReference centiles for serum ferritin and percentage of transferrin saturation, with application to mutations of the HFE gene.
BACKGROUND The gene that causes most cases of hereditary hemochromatosis is designated HFE. Individuals with mutations in the HFE gene may have increased serum iron, transferrin saturation, and ferritin concentrations relative to individuals with the wild-type genotype. METHODS We generated reference centiles for percentage of transferrin saturation and serum ferritin concentrations in normal...
متن کاملA population-based study of the clinical expression of the hemochromatosis gene.
BACKGROUND AND METHODS Hereditary hemochromatosis is associated with homozygosity for the C282Y mutation in the hemochromatosis (HFE) gene on chromosome 6, elevated serum transferrin saturation, and excess iron deposits throughout the body. To assess the prevalence and clinical expression of the HFE gene, we conducted a population-based study in Busselton, Australia. In 1994, we obtained blood ...
متن کاملHemochromatosis: clinical implications of genetic testing.
Hemochromatosis is one of the most common genetic diseases affecting Canadians of European ancestry. However, too often this disease is diagnosed in people who do not have it and is missed in those who do. By the time a diagnosis is made on the basis of symptoms, irreversible organ damage has often occurred. A missense mutation (the C282Y cysteine-to-tyrosine substitution) on chromosome 6 of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2000